NF1 microdeletions in pediatric acute leukemias. (A) Chromosome 17 ideogram and corresponding oligo array-CGH plot of patient DNA/control DNA ratios (blue tracing) versus the dye-swap experiment (red tracing) for T-ALL patient no. 2736. (B) Detailed visualization of the NF1 microdeletion at chromosomal band 17q11 in T-ALL patient no. 2736. Hybridization signals around the −2X or +2X lines represent loss of the corresponding region in the patient DNA. (C) Detailed analysis of the centromeric (left panel) and telomeric (right panel) breakpoint of the NF1 microdeletion in patient no. 2736. (D) Overview of oligo array-CGH results in the chromosomal region 17q11.2 for 3 patients with T-ALL and 2 patients with AML with del(17)(q11.2). The 60-mer oligos present on the DNA array and located in this genomic area, as well as the specific genes located in this region with their transcription direction, are shown. Arrows above the indicated genes represent the direction of transcription. N indicates normal; L, loss; cen, centromere; and tel, telomere.