Schematic representation of human fibronectin type I, II, and III modules and superposition of 4th to 5th type I repeats (FN-I_4-5) 3-dimensional structure with CNGRC/GNGRG most populated structures. Modules containing NGR and RGD sequences (→). Superposition of the fibronectin (FN)–I_4-5-PDB structure (in blue) and GNGRG hairpin of fibronectin (light blue) with the most populated structures of the CNGRC and GNGRG peptides (in red), predicted by molecular dynamics simulation.⁵⁹  This scheme has been modified from Di Matteo et al.⁵⁹