LRP's intracellular domain and pAkt interact in perivascular astrocytes. (A) Coimmunoprecipitation studies in brain extracts from Wt and tPA^−/− mice 1 hour after MCAO. tPA^−/− were either left untreated (−tPA) or injected directly into the ischemic tissue with tPA (1 μM;+tPA). (B) Coimmunoprecipitation studies in brain extracts from Wt mice 1 hour after MCAO. Animals were either left untreated (MCAO) or injected into the ischemic tissue with RAP (9 μM; MCAO + RAP).