Genomic mapping of chromosome arm 9p. (A) Profiles generated using the copy number analyzer for Affymetrix GeneChip software. Ideograms of chromosome 9 are positioned vertically and flanked by a blue copy number plot to the right, which follows 2.0 for normal copy number. To the left of each ideogram, heterozygous SNP calls are shown in green, and the likelihood of LOH is represented by the thickness of the blue bar. Thus, the 4 profiles show a patient with (i) a monoallelic terminal deletion of 9p, (ii) an interstitial biallelic deletion, (iii) both a terminal monoallelic and interstitial biallelic deletion, and (iv) CNN LOH. (B) An array CGH profile for chromosome 9. The chromosome ideogram is positioned vertically with the red line following a log ratio of 0.0 for normal copy number. This profile shows a patient with a terminal monoallelic and interstitial biallelic deletion. The shaded areas define regions of copy number change ac-cording to a z-score algorithm. (C) FISH analysis. Vysis p16(9p21) (red)/CEP9 (green) probe showing (i) normal pattern, (ii) monoallelic deletion, or (iii) biallelic deletion. WRGL CDKN2A (green)/Centromere 9 (red) deletion probe showing (iv) normal pattern, (v) monoallelic deletion, or (vi) biallelic deletion.