VEGF extracellular signaling inhibition is similar to another tyrosine kinase pathway, BMP. Binding of the sVEGFR-1 inhibits VEGF action and allows movement through the extracellular matrix. VEGF is allowed to signal only after degradation of sVEGFR-1 by MMP-7 (left). This inhibition of signaling is similar to that seen in the BMP extracellular cascade (right).