Platelet counts and platelet responses by study week. (A) Median (25th [Q1] and 75th [Q3] percentiles) platelet counts by study week. Median platelet counts increased sharply during the first 4 weeks of treatment and then more gradually through week 16. (B) Percentage of patients with a platelet response over time. A platelet response was defined as a platelet count of 50 × 10⁹/L or more that was at least double the platelet count at baseline in the absence of rescue medication within the preceding 8 weeks. After 1 dose, 30% of patients achieved a platelet response, and after 3 doses, 51% achieved a response. Over the course of the study, a platelet response was observed in 87% of all patients.