Histopathologic profile of age-related EBVLPD. (A) Hodgkin and Reed-Sternberg (HRS)–like giant cells were frequently observed scattered among reactive cells. These cells showed CD20 expression (B), in addition to positive signals for EBNA2 (C). Images were acquired using an Olympus AX80 microscope (Olympus, Tokyo, Japan) with a 100×/1.35 oil Iris lens (Olympus). Staining was with L26/CD20 and EBNA2 (Dako, Glostrup, Denmark). Images were captured with an Olympus DP70 camera and processed with Adobe Photoshop Elements, version 7 (Adobe Systems, San Jose, CA).