In vivo carotid artery injury model. (A) 8 Gp6^−/− SHORT mice were compared with 10 Gp6^−/− LONG mice, as indicated on the abscissa. The data are depicted as a box plot, where the bold horizontal line represents the median, the box represents the second and third quartiles, and the vertical lines indicate the limits of the data range. The time to occlusion (ordinate) for the 8 Gp6^−/− SHORT mice (4 male mice; 4 female mice) was 8.6 ± 1.2 minutes (mean ± SD). In contrast, the time to occlusion of 10 Gp6^−/− LONG mice (5 male mice; 5 female mice) ranged from 11.5 to at least 25 minutes, with a median of at least 25 minutes. The difference in time to occlusion between Gp6^−/− LONG and Gp6^−/− SHORT mice was statistically significant (P < .001). (B) Correlation between time to occlusion (ordinate) and haplotype at Mh (abscissa). For 6 mice that are homozygous 129 × 1/SvJ at Mh, the mean time to occlusion was 8.2 (± 0.9) minutes (mean ± SD). For 5 mice that are heterozygous 129 × 1/SvJ/C57BL/6J at Mh (HET), the time to occlusion was significantly increased to 11 (± 1) minute (mean ± SD; P < .001). In marked contrast, occlusion was not observed (time to occlusion ≥ 25 minutes) in any of the 7 mice that were homozygous C57BL/6J at Mh.