Effect of IUT on hydroxyproline and expression of osteogenic genes. (A) qRT-PCR using markers specific for human cDNA for OC, OP, OPG, BMP, and OSX normalized to human β-actin. Results are expressed as RNA levels fold increase in bone and bone marrow relative to basal levels in undifferentiated human fetal MSCs. (B) Hydroxyproline content (μg/mg protein) in 4-week-old OIM + IUT mice (n = 11) that received transplants and OIM mice that did not receive transplants (n = 17). Results are presented as means (±SD). **P < .01.