Uniparental disomy and uniparental trisomy in MCL. (A) Ideogram of the distribution of the UPD/UPT regions detected by SNP arrays. UPD/UPTs are represented on the left side of each chromosome; thin bars represent UPD regions, whereas thick bars represent gained/amplified regions with LOH (UPT). UPD/UPTs detected in the 10 cell lines are indicated in green, whereas UPD/UPTs detected in the primary MCL samples are indicated in blue. Acquired UPDs detected only in tumor cells were indicated in orange. The more recurrent overlapping regions were shaded in gray. (B) Chromosome 9 total/partial UPDs and homozygous deletions detected in MCL cell lines. Chromosome 9 profile is represented from pter (left) to qter (right). For each cell line, the top panel represents copy number alteration (genome smooth analysis [GSA], P value) and the bottom panel represents LOH (−log10 LOH P value). Regions with genomic losses and concomitant LOH are underlined with thick red bars, homozygous deletions (HD) are indicated with dark red squares, and regions with UPD are underlined with thick black bars. MINO showed a whole chromosome 9 UPD, whereas the 3 remaining cell lines showed a 9q UPD and concomitant loss of 9pter-p21. REC1 and MAVER1 showed homozygous deletions of CDKN2A gene at 9p21.3, and MAVER1 had 2 additional homozygous deletions (indicated by asterisks; Table 1).