Leukemic cells are predominantly blastlike and Lin⁻Kit⁺. (A) Hematoxylin and eosin–stained histology sections of spleen (i), liver (ii), and BM (iii) from Runx2-induced leukemic mice. Wright-Giemsa staining of peripheral blood (iv) showing a predominant blastlike population () and a monocytic population (). (B) FACS analysis of GFP (expressed from MSCV-iresGFP), lineage markers (Gr1, Mac1, B220, CD3, Ter119), and progenitor marker (c-Kit) in spontaneous leukemia (top) and 2 Runx2-induced leukemia (R2-7, R2-3, middle and bottom).