Defective erythropoiesis in Ank-1^1674/1674 E18.5 embryos. (A) Genotype distribution of wt, Ank-1^1674/+, and Ank-1^1674/1674 mice at E18.5. (B) SEM of RBC from wt and Ank-1^1674/1674 embryos at E18.5. (C,D) RBC and hematocrit in wt, Ank-1^1674/+, and Ank-1^1674/1674 embryos at E18.5. Student t tests were performed: the RBC count P value between wt and Ank-1^1674/+ (P = .34); and between wt and Ank-1^1674/1674 (P = .009). P values for the hematocrit between wt and Ank-1^1674/+ (P = .406); and between wt and Ank-1^1674/1674 (P = .028). P values less than .05 were considered significant. (E) Genotype distribution of live wt, Ank-1^1674/+ and Ank-1^1674/1674 mice at birth. Error bars represent SD in all figures.