Reduced mononuclear cells attracting chemokines in opt_sgp130Fc transgenic mice. (A) Levels of endogenous KC in inflamed air pouches of opt_sgp130Fc transgenic and WT mice 4 hours, 12 hours, and 72 hours after carrageenan challenge. KC concentrations were determined by ELISA. (B) MCP1 in inflamed air pouches of opt_sgp130Fc transgenic and WT mice 4 hours, 12 hours, and 72 hours after carrageenan challenge. KC and MCP1 concentrations were determined by ELISA. Four to 7 mice per group. Data are represented as mean values plus or minus SD (**P < .01).