c-Myc induces de novo KIR expression in the NK92 cell line. NK92 cells were transduced with either (A) MSCV–c-myc or (B) MSCV-egfp vectors and cultured for a period of 4 weeks. (C) KIR-negative and (D) KIR-positive cells from c-Myc–transduced cultures were then sorted by flow cytometry into separate cultures and phenotyped for CD56 and KIR expression 8 weeks later.