APO866 induces time-dependent cell death in malignant cells from several hematologic malignancies. Time course analysis of cell death induced by 10 nM APO866 on cancer cells from cell lines ML-2 (A), Namalwa (B), and Jurkat (C); and primary cells from patients with various hematologic malignancies, AML (D), ALL (E), CLL (F), and ML (G). Cell death was assessed as in Figure 1. Data are derived from at least 3 independent experiments.