Differentially regulated apoptosis-related genes in leukemic LGLs compared with activated enriched normal CD8⁺ cells. (A) Apoptosis-related genetic signature unique to leukemic LGLs. The genes that were differentially regulated between leukemic LGLs and activated enriched normal CD8⁺ cells were identified (at least 2-fold change and 1% FDR). A total of 128 genes belonging to GO category “apoptosis” were differentially expressed in leukemic LGLs compared with activated enriched normal CD8⁺ cells (AcCD8⁺). Each row in the cluster image represents an individual gene, and each column represents an individual sample from LGL leukemia patient or healthy donor. The relative transcript abundance of each gene is color coded. A red color indicates high expression, black indicates intermediate expression, and green indicates low expression. (B) Differentially regulated genes between leukemic LGLs and activated enriched CD8⁺ cells were imported in GenMAPP software for visualization. Known apoptosis-related genes and their relation are shown. The genes constitutively up-regulated in leukemic LGLs compared with activated normal enriched CD8⁺ cells are shown in red, genes constitutively down-regulated in leukemic LGLs are shown in blue, and those in white show no change in expression between 2 phenotypes. The number accompanying each gene indicates fold change in expression.