SHIP deficiency impairs in vivo production of SDF-1/CXCL12. (A) Scatter plots indicating the mean and range for the concentration of SDF-1/CXCL12 in the blood plasma of SHIP^−/− and WT littermates. (B) Scatter plots indicating the mean and range for the concentration of SDF-1/CXCL12 in the BM plasma of SHIP^−/− and WT littermates. The data are pooled from multiple assays derived from a minimum of 7 different samples for each genotype. Significance was established using the unpaired Student t test (**P < .005; ***P < .001). ■ represent SHIP^−/− samples; , WT samples.