Inhibition of CD40L-induced cytokine secretion of primary CLL cells. Patient CLL cells were cultured with huIgG1 (10 μg/mL) or HCD122 (10 μg/mL) in the presence or absence of CHO-CD40L cells (1:2 ratio). Culture supernatants were collected at 24 hours and assayed for cytokine levels by the Meso Scale Discovery (MSD) Multi-Array Platform. Graphs represent data from one representative CLL patient. Values represent mean (± SD) of triplicate measurements.