Induced SHIP deficiency delays rejection of MHC-mismatched, vascularized heart allografts. (A) Example of an anastomosed heart early after reperfusion. The heart is located in the right lower abdomen of the recipient mouse, and contractions can be palpated through the abdominal wall after closure. (B) Kaplan-Meier step-functions for graft survival in MxCreSHIP^flox/flox mice after induction of SHIP deficiency (red), SHIP^flox/flox controls (dashed black) and C57BL/6J mice (blue). The latter group was treated with an identical polyI/C (labeled pI/C) regimen as that given to MxCreSHIP^flox/flox mice. P < .01 for MxCreSHIP^flox/flox versus SHIP^flox/flox graft survival. P < .05 for MxCreSHIP^flox/flox versus C57BL/6J graft survival.