Transport of dasatinib and imatinib in primary CML cells. Differences on dasatinib (A) and imatinib (B) uptake on primary cells. The effect of hOCT1 inhibitor prazosin on the uptake of radiolabeled dasatinib (A) and imatinib (B) into patients expressing low (, n = 8) and high (■, n = 7) hOCT1 levels was examined. The uptake of imatinib is inhibited in both low and high hOCT1 samples (P = .001 and P = .04, respectively), but there was no effect on the uptake of dasatinib. Data represent mean plus or minus SEM from 7 (■) or 8 () hOCT1 expresses.