SALL4 binds and transcriptionally regulates genes involving various pathways and biologic functions. Gene-expression changes derived from NB4 cell mRNA expression profiling following SALL4 reduction were classified and compared with ChIP-chip data. represent the number of SALL4-bound promoters identified from the ChIP-chip assay; represent the number of statistically significant (P < .05) altered mRNA transcripts in SALL4 knockdown NB4 cells. Their distribution in each signaling pathway (A) or biologic functional category (B) was determined by Ingenuity Pathway Analysis. The P values presented for each category are based on overrepresentation and calculated against the knowledge base provided by Ingenuity Pathway Analysis.