Pharmacokinetic-pharmacodynamic modeling of tumoral progression and rituximab plasma concentrations. (A) Pharmacodynamic parameters describing tumor mass in treated and untreated mice. Results are given as mean (interindividual CV). (B) Relationship between tumor burden and k_drug, a pharmacodynamic parameter that quantifies rituximab efficacy, observed values (●), and model-predicted values (continuous line; r² = 0.89).