Kaplan-Meier estimates of event-free survival or overall survival according to NOTCH1 mutation. (A) Event-free survival (EFS); (B) overall survival (OS). Patients with ALL with a wild-type genotype of NOTCH1 (black line; n = 53) have a significantly higher risk of event or death than patients with ALL with mutated NOTCH1 (dashed line; n = 88).