Kaplan-Meier estimates of overall survival of patients with ALL according to the presence of a NOTCH1 and/or FBXW7 mutations and according to the chemotherapeutic protocol. Survival of patients with a wild-type genotype of NOTCH1 and FBXW7, treated with the LALA-94 protocol (n = 25); survival of patients with a wild-type genotype of NOTCH1 and FBXW7, treated with the GRAALL-2003 protocol (n = 15); patients with a mutated genotype of NOTCH1 and/or FBXW7, treated with the LALA-94 protocol (n = 62); patients with a mutated genotype of NOTCH1 and/or FBXW7, treated with the GRAALL-2003 protocol (n = 39).