Vaccination with DCs loaded with irradiated, mAb-coated tumor cells can eradicate preexisting tumor in combination with chemotherapy. Groups of 12 mice received 5000 38C13 lymphoma cells subcutaneously on day 0 and were treated on days 0 and 15 with either DCs loaded with irradiated, mAb-coated tumor cells, Id-KLH, or HBSS. On day 8, the animals received 100 mg/kg cyclophosphamide intraperitoneally. Animals were then followed for tumor growth and killed when their tumors reached 1.4 cm in diameter. Data are representative of 2 independent experiments.