Treatment with panobinostat causes significant tumor growth delay and prolongs survival of mice implanted with CTCL cells. (A) HH cells were injected into the flank of female athymic nude mice. Treatment began when tumors were approximately 100 mm³. Mice were treated intraperitoneally with DMSO, or 10 mg/kg or 20 mg/kg panobinostat 3 days per week for 4 weeks. n = 8 per group. Mean tumor volumes ± SEM are shown. (B) Female athymic nude mice were injected in the lateral tail vein with HH cells. The cells were allowed to engraft for 28 days before initiation of treatment. Mice were treated intraperitoneally with DMSO or 20 mg/kg panobinostat 3 days per week for 4 weeks. n = 10 per group. Survival of the mice in both groups (vehicle and panobinostat) is represented by Kaplan-Meier plot.