Association of a high CI with other high-risk factors and genomic instability. (A) A Venn diagram showing overlap between tumors with high CI, high PI, and t(4;14). The overlap is less than 50% for 2 of these features, and only 5 (4%) patients have all 3 features. (B) An enrichment plot showing clustering of genes constituting a chromosome instability signature among the top-ranking genes overexpressed in tumors with high CI.