Figure 2
NRASG12V expression is required for AML persistence. (A) Transplantation of AML BM cells via intravenous injection. Half of the transplanted SCID mice were continuously treated with Dox. (B) Kaplan-Meier survival curve in mice with or without Dox treatment. Chronic Dox treatment significantly delays or suppresses the establishment of AML in SCID mice after transplantation of the BM cells from triply transgenic mice with AML (P = .012). The numbers in circles represent each of the 4 independent AML BM cells (AML1, 2, 3, and 4) transplanted into SCID mice.
