Figure 2
EBV genome loads in peripheral blood B-cell subsets. EBV genome loads in purified naive (N), isotype-switched memory (SM), and nonswitched memory (NSM) B cells were determined by quantitative PCR and the results expressed as EBV genomes per 106 cells. Median values for each subset (shown by the horizontal bars) are 6.0 × 101, 5.0 × 103, and 1.1 × 103, respectively, for chronic virus carriers, and 3.9 × 103, 7.0 × 105, and 2.8 × 105, respectively, for IM donors. Restricting the analysis to those persons in which all 3 subsets were sorted, median values were unchanged for chronic carriers and 4.6 × 103, 9.9 × 105, and 2.8 × 105, respectively, for IM donors. Samples with less than 10 copies per 106 cells are reported as negative.
