American Society of Hematology

ADAMTS-18 Binds and Clusters β3 integrins and Destroys platelet aggregates. (A) Under resting conditions, the endothelium constitutively releases a small amount of ADAMTS-18. (B) Endothelial activation by thrombin enhances the secretion of ADAMTS-18, which binds to platelet αIIbβ3. Thrombin cleaves ADAMTS-18 to produce an active 45-kDa C-terminal fragment, which (C) clusters β3 integrins. (D) Clustering activates12-lipoxygenase and NADPH oxidase to regulate thrombus size by oxidative fragmentation. (TSP, thrombospondin; PAR-1, protease activated receptor-1; H2O2, hydrogen peroxide.)

ADAMTS-18 Binds and Clusters β₃ integrins and Destroys platelet aggregates. (A) Under resting conditions, the endothelium constitutively releases a small amount of ADAMTS-18. (B) Endothelial activation by thrombin enhances the secretion of ADAMTS-18, which binds to platelet α_IIbβ₃. Thrombin cleaves ADAMTS-18 to produce an active 45-kDa C-terminal fragment, which (C) clusters β₃ integrins. (D) Clustering activates12-lipoxygenase and NADPH oxidase to regulate thrombus size by oxidative fragmentation. (TSP, thrombospondin; PAR-1, protease activated receptor-1; H₂O₂, hydrogen peroxide.)

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