Global up-regulation of red and white hematopoietic lineages in vhl mutants. In situ hybridizations reveal a global up-regulation of both red and white hematopoietic lineages, as shown at 7.5 dpf. Increased expression of red lineage markers scl/tal-1 (HSC, erythrocytes), c-myb (HSC), gata1 (immature erythrocytes), and βE1 globin (differentiated erythrocytes), and white lineage markers ikaros (immature lymphocytes), lck (differentiated lymphocytes), mpo (neutrophils), and l-plastin (monocytes) is observed, predominantly in the horseshoe-like PHT (→) adjacent to the glomerulus. c-myb, ikaros, lck, and l-plastin are also expressed in the bilateral thymus (). Accumulated blood cells in the heart remain scl, ikaros, and βE1 globin positive. Original magnification ×5.