Cycling of CD4⁺ and CD8⁺ T cells in response to rhIL-7. (A) Increased CD4⁺ and CD8⁺ T-cell cycling was seen on days 1 and 4, returning to baseline by day 14. (B) The degree of T-cell proliferation was higher at higher dosing levels. ● represents placebo participants () and ▲ represents rhIL-7 participants (). (C) Absolute counts of Ki67⁺ T cells during study participation by rhIL-7 dose. ● represents placebo participants () and rhIL-7 participants are represented by ▲ (3 μg/kg), ■ (10 μg/kg), ♦ (30 μg/kg), and X (60 μg/kg). P values represent comparisons between rhIL-7 and placebo recipients by Wilcoxon rank sum test.