Copy number integrity of the microRNA genome in DLBCL. (A) Genomewide display of loss (blue) and gain (red) of chromosome material targeting the miRNA loci in 73 DLBCL samples. (B) Focal loss of genomic material encompassing miR-491 and miR-31 on chromosome 9 in 5 primary tumors; normal sample DNA also analyzed is displayed alongside. (C) Broad gain of chromosome material targeting the X chromosome in 5 DLBCLs with a diploid tumor is also shown. For all displays, each column represents a different sample (numerical ID for primary tumors), and each row represents an individual oligonucleotide probe. Chromosome numbers are listed on the left side of the figure. The site designation indicates the primary tumor location (L indicates lymph node; X, extranodal); immunohistochemistry (IHC), was performed as described by Hans et al⁷  to classify the tumors according to germinal center (G) or non-GC (N) categories. The T-cell infiltrate was quantified as described in Table S1: < 5% (1), 5%-15% (2), and 15%-25% (3).