Location of missense mutations. (Top panel) Schematic representation of the CBL protein showing the tyrosine kinase binding (TKB), linker, RING, proline-rich (P-rich), and ubiquitin-associated/leucine zipper (UBA/LZ) domains. (Bottom panel) ClustalW alignment of the entire linker and RING domains plus part of the distal sequence. The RING domain is shaded in gray with the defining C and H residues shaded pale blue. Residues affected by missense mutations found in this study are indicated by ▼.