Clinical observations. (A) Patient 1 with initial progression and subsequent mCR lasting for 12 months. ■ indicates the percentage of blasts in bone marrow; and ▴, the time points of vaccinations and the stripes periods of chemotherapy. (B) Patient 9 with initial progression and subsequent transient reduction of PB blasts. The amount of peripheral blasts per nanoliter is shown. ▴ indicates the time points of vaccinations; and the stripes, periods of chemotherapy. (C) Patient 17 with major erythroid response and a molecular response with complete clearance of the trisomy 8 disease marker. (belonging to the left axis) indicates the number of RBC transfusions per months; ■ (belonging to the right axis) shows the percentage of positive nuclei for trisomy 8; and ▴, the time points of vaccinations.