Figure 5
Figure 5. Differential immune responses as a result of differential BM-DC homing. (A) Increase in cell number in DC-targeted lymphoid tissues (spleen, PLNs, MLNs, LLNs) on day 1 and day 2 after intravenous or intraperitoneal injection. Data show the mean from 3 mice ± standard deviation (SD) (except uninjected control group, n = 5). (B) Relative biodistribution of Luc+ DCs in spleen, PLNs, and MLNs 3 days after intravenous or intraperitoneal injection in NOD mice. All data show the mean from 3 mice ± SE. (C) Percentage of CFSE+ DCs in spleen, PLNs, and MLNs 2 days after intravenous or intraperitoneal injection in NOD mice. Data show the mean from 3 mice ± SD. (D) Mean fluorescence intensity of CD25 expression on CD4+ CD25+ T cells in spleen, PLNs, and MLNs 2 days after intravenous or intraperitoneal injection of CFSE+ DCs. Data show the mean from 3 mice ± SD (except uninjected control group, n = 5). t test was used for all statistical analyses.

Differential immune responses as a result of differential BM-DC homing. (A) Increase in cell number in DC-targeted lymphoid tissues (spleen, PLNs, MLNs, LLNs) on day 1 and day 2 after intravenous or intraperitoneal injection. Data show the mean from 3 mice ± standard deviation (SD) (except uninjected control group, n = 5). (B) Relative biodistribution of Luc+ DCs in spleen, PLNs, and MLNs 3 days after intravenous or intraperitoneal injection in NOD mice. All data show the mean from 3 mice ± SE. (C) Percentage of CFSE+ DCs in spleen, PLNs, and MLNs 2 days after intravenous or intraperitoneal injection in NOD mice. Data show the mean from 3 mice ± SD. (D) Mean fluorescence intensity of CD25 expression on CD4+ CD25+ T cells in spleen, PLNs, and MLNs 2 days after intravenous or intraperitoneal injection of CFSE+ DCs. Data show the mean from 3 mice ± SD (except uninjected control group, n = 5). t test was used for all statistical analyses.

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