SNX-2112 induces cytotoxicity against MM cells. (A,B) MM.1S (■), MM.1R (□), U266 (▴), INA-6 (Δ) RPMI8226 (●), RPMI Dox40 (○) OPM1(♦), and OPM2 (◇) MM cell lines. (C) Normal PBMNCs (1 (■), 2 (□), 3 (▴), n = 3); and (D) MM patient cells (1 (■), 2 (□), 3 (▴), n = 3) were cultured for 48 hours in the presence of SNX-2112 or 17-AAG. Cell growth was assessed by MTT assay, and data represent mean plus or minus SD of triplicate cultures.