Frequency plot of all CLL samples versus normal CNV database. The frequency plot for 58 CLL samples is shown in blue and that of 500 “normal” (ie, disease-free) individuals is shown in red. The red frequency plot shows CNVs in the human genome and was used to eliminate any CNVs in our data exposed through copy-neutral LOH (ie, regions in which CNVs overlap with lesions observed in CLL). Most lesions observed in CLL are deletions and trisomy 12. Regions of interest are marked with arrows.