Control mice of the FV-transgenic lines inoculated with GAS strain UMAA2616. F5^+/−, Tg⁺F5^+/−, Tg⁺F5^+/+, and F5^+/+ mice for all 3 FV-transgenic lines were infected with UMAA2616 at doses of 3.6 × 10⁶ to 2.6 × 10⁸ CFU. Data were pooled from 7 independent experiments using littermates, constituting a total of 18 F5^+/−, 27 Tg⁺F5^+/−, 3 Tg⁺F5^+/+, and 7 F5^+/+ mice.