AlbfvB mice inoculated with GAS strain UMAA2616. P values for differences between the survival curves are indicated in all panels. The solid line represents Tg⁺F5^−/−; dashed lines, F5⁺ littermate controls. (A) Inoculum of 3.6 × 10⁶ CFU. Data were pooled from 4 independent experiments (totaling 17 AlbfvBTg⁺F5^−/− mice and 32 littermate F5⁺ controls), at doses ranging from 1.2 × 10⁶ to 4.9 × 10⁶ CFU. (B) Inoculum of 2.5 × 10⁷ CFU. Data were pooled from 2 independent experiments (totaling 6 AlbfvBTg⁺F5^−/− mice and 18 littermate F5⁺ controls) at doses of 1.4 × 10⁷ and 3.6 × 10⁷ CFU. (C) Inoculum of 2.6 × 10⁸ CFU. Data were from a single experiment with 5 AlbfvBTg⁺F5^−/− mice and 5 F5⁺ littermate controls. (D) Pooled data from all the experiments shown in panels A to C (a total of 28 AlbfvBTg⁺F5^−/− mice and 55 F5⁺ littermate controls).