AlbfvC and Pf4fvA mice inoculated with GAS strain UMAA2616. P values for survival differences are indicated in each panel. — represents Tg⁺F5^−/−; ----, F5⁺ littermate controls. (A) AlbfvC mice at an inoculum of approximately 4 × 10⁶ CFU. Data were pooled from 2 independent experiments (totaling 17 AlbfvCTg⁺F5^−/− mice and 32 littermate F5⁺ controls), at doses of 3.7 × 10⁶ and 4.4 × 10⁶ CFU, respectively. (B) AlbfvC mice at an inoculum of 3.6 × 10⁷ CFU. Data were derived from 1 experiment (4 AlbfvCTg⁺F5^−/− mice and 22 littermate F5⁺ controls). (C) AlbfvC mice at an inoculum of 2.6 × 10⁸ CFU. Data were derived from 1 experiment (4 AlbfvCTg⁺F5^−/− mice and 9 littermate F5⁺controls). (D) Pooled data from all experiments (25 AlbfvCTg⁺F5^−/− mice and 63 littermate F5⁺ controls). (E) Comparison of the AlbfvC and AlbfvB lines (combined from Figures 3D and 2D). P value of the difference between Tg⁺F5^−/− mice from AlbfvC and AlbfvB lines is indicated. (F) Pf4fvA mice at an inoculum of 1.4 × 10⁷ CFU. Data were derived from 1 experiment (6 Pf4fvATg⁺F5^−/− mice and 25 littermate F5⁺ controls).