Figure 7
Figure 7. FV Leiden mice inoculated with GAS strain UMAA2616. Data were pooled from 11 independent experiments with UMAA2616 doses ranging from 106 to 108 CFU. The total number of mice in each group are 68 hPLG−F5+/+, 74 hPLG+F5+/+, 61 hPLG−F5Q/+, and 57 hPLG+F5Q/+. P values for survival difference are indicated. Among the P values indicated are difference between hPLG−F5+/+ and hPLG−F5Q/+ (P > .26), difference between combined hPLG− (hPLG−F5+/+ and hPLG−F5Q/+) and combined hPLG+ (hPLG+F5+/+ and hPLG+F5Q/+) (P < 5.5 × 10−9), and difference between hPLG+F5Q/+ and hPLG+F5+/+ (P > .52).

FV Leiden mice inoculated with GAS strain UMAA2616. Data were pooled from 11 independent experiments with UMAA2616 doses ranging from 106 to 108 CFU. The total number of mice in each group are 68 hPLG−F5+/+, 74 hPLG+F5+/+, 61 hPLG−F5Q/+, and 57 hPLG+F5Q/+. P values for survival difference are indicated. Among the P values indicated are difference between hPLG−F5+/+ and hPLG−F5Q/+ (P > .26), difference between combined hPLG− (hPLG−F5+/+ and hPLG−F5Q/+) and combined hPLG+ (hPLG+F5+/+ and hPLG+F5Q/+) (P < 5.5 × 10−9), and difference between hPLG+F5Q/+ and hPLG+F5+/+ (P > .52).

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