Figure 6
Figure 6. Results from a single CB transplanted into 3 mice. Top graph shows the comparison between 3 mice that each received a transplant of 3% of whole CB-6 (gray lines), and the 2 separate CB transplantation experiments (CB-4 and CB-5; dashed lines). Although the independent transplantation experiments yield differing degrees of telomere loss after transplantation, the mice that received a transplant within the same experiment with the same CB show indistinguishable telomere loss. Subsequent graphs compare the telomere length of primitive CD34+ cells with terminally differentiated CD15/66b+ or CD3+ cells before and after transplantation (black and gray lines, respectively), and show similar changes in telomere length in the 3 mice that received a transplant of the same CB. Right panel shows the degree of telomere loss between pretransplantation and posttransplantation CD34+ cells (top bar chart), and the degree of telomere loss between CD34+ and differentiated cells in untransplanted CB, and the 3 mice that underwent transplantation (subsequent bar charts).

Results from a single CB transplanted into 3 mice. Top graph shows the comparison between 3 mice that each received a transplant of 3% of whole CB-6 (gray lines), and the 2 separate CB transplantation experiments (CB-4 and CB-5; dashed lines). Although the independent transplantation experiments yield differing degrees of telomere loss after transplantation, the mice that received a transplant within the same experiment with the same CB show indistinguishable telomere loss. Subsequent graphs compare the telomere length of primitive CD34+ cells with terminally differentiated CD15/66b+ or CD3+ cells before and after transplantation (black and gray lines, respectively), and show similar changes in telomere length in the 3 mice that received a transplant of the same CB. Right panel shows the degree of telomere loss between pretransplantation and posttransplantation CD34+ cells (top bar chart), and the degree of telomere loss between CD34+ and differentiated cells in untransplanted CB, and the 3 mice that underwent transplantation (subsequent bar charts).

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