Wound closure of full-thickness wounds is delayed in Vav3^−/− and Vav1^−/−/Vav3^−/− mice. (A) Representative macroscopic aspects of wounds from Vav3^−/−, Vav1^−/−/Vav3^−/− and WT mice at different healing stages. (B,C) Statistical analysis of 24 wound areas quantified at days 0, 3, 5, 7 and 10 after wounding expressed as percentage of the initial (day 0) wound size for WT, Vav3^−/− and Vav1^−/−/Vav3^−/− mice. Results given as mean ± SD (n = 6) reflect 1 of 3 independent experiments. *P < .05 by Mann-Whitney test.