Figure 1
Figure 1. Increased BBB permeability in P-selΔCT/ΔCT mice. (A) Quantification of EBD accumulation in the brain of P-selΔCT/ΔCT mice compared with WT. Data represent EBD extravasation calculated from A620 OD/g. n = 17 for WT and n = 31 for P-selΔCT/ΔCT mice. (B) Comparison of EBD accumulation between the right (RH, ▴) and left hemisphere (LH, ▵) in each animal. Ovals indicate the animals with a difference between RH and LH. (C) Representative images from confocal microscopy in the cortex of 4- to 5-month-old mice injected with EBD (red) 6 hours before perfusion with large dextran (green) at the time of sacrifice. Top panels show section of cerebrum from a WT; bottom panels are from P-selΔCT/ΔCT mice. Arrow points to the accumulation of EBD outside of the vessel in the left hemisphere of the P-selΔCT/ΔCT mice. Data represent mean ± SEM.

Increased BBB permeability in P-selΔCT/ΔCT mice. (A) Quantification of EBD accumulation in the brain of P-selΔCT/ΔCT mice compared with WT. Data represent EBD extravasation calculated from A620 OD/g. n = 17 for WT and n = 31 for P-selΔCT/ΔCT mice. (B) Comparison of EBD accumulation between the right (RH, ▴) and left hemisphere (LH, ▵) in each animal. Ovals indicate the animals with a difference between RH and LH. (C) Representative images from confocal microscopy in the cortex of 4- to 5-month-old mice injected with EBD (red) 6 hours before perfusion with large dextran (green) at the time of sacrifice. Top panels show section of cerebrum from a WT; bottom panels are from P-selΔCT/ΔCT mice. Arrow points to the accumulation of EBD outside of the vessel in the left hemisphere of the P-selΔCT/ΔCT mice. Data represent mean ± SEM.

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