Plasma lipids and lipoprotein profiles in P-sel^+/+/apoE^−/− and P-sel^ΔCT/ΔCT/apoE^−/− mice. Plasma was collected from individual mice of both sexes, fasted for 4 hours. (A) Total cholesterol, unesterified cholesterol, phospholipid, and triglyceride levels in plasma from P-sel^+/+/apoE^−/− (■) and P-sel^ΔCT/ΔCT/apoE^−/− (□) mice. Data represent mean ± SEM (n = 6-9). Error bars indicate SEM. (B) Plasma samples from P-sel^+/+/apoE^−/− (●) and P-sel^ΔCT/ΔCT/apoE^−/− (○) individual animals were size fractionated by FPLC, and the total cholesterol content of each fraction was determined. The chromatograms are the average of multiple individually determined profiles (n = 4). Approximate elution positions of native very low density lipoprotein (VLDL), IDL/LDL, and HDL particles are indicated by brackets.