TAX-LUC mice spontaneously develop bioluminescent tumors. (A) BLI of TAX-LUC mice with peripheral tumors on the nose, ear, foot, and tail. (B) Hematoxylin and eosin (H&E)–stained section of a bioluminescent inflammatory tail nodule (red arrow). Bar = 1 mm. (C) Coregistration of photograph, BLI, and X-ray images. (D) Fluorescence activated cell sorting (FACS) histogram of a tumor homogenate. (E) Immunohistochemistry (IHC) on sequential sections of a bioluminescent tumor (white inset) and liver involvement (red inset with black circle) stained with Tax or prebleed serum. Bar = 50 μm. (F) Wright/Giemsa-stained peripheral blood smear from an animal with advanced lymphoma. Red arrows indicate multinucleated LGL cells. (G) Rate of tumor development in TAX-LUC (n = 11) and GZB-TAX (n = 9) mice. Color scale for panels A and C is ×104 photons/s/cm2/sr.
