Multipoint linkage and allelic expression analysis of PLAU in QPD. (A) Results of multipoint linkage using 4 microsatellite markers (positions are shown relative to GATA121A08). The genetic location of PLAU between markers D10S1432 and D10S1136 is indicated on the x-axis, which is the region with the highest LOD score for this analysis (+11). (B) Graph of reverse transcriptase–quantitative PCR (RT-qPCR) analyses of PLAU alleles for SNP rs4065 in different tissues and indicates the measured ratios of T/C alleles in saliva cells, CD34⁺ cells, and platelets in samples from 5 controls and 4 individuals with QPD. T/C ratios were significantly different for QPD compared with control samples for all tissues (P = .016).