Phenotypic defects in the HSC compartment of Mll5^−/− mice. (A) Reduced frequency of Lin⁻/Sca1⁺/Kit⁺ (LSK) cells (middle panels) and altered CD34/Flt3 subset composition (right panels) in Mll5^−/− mice. (Left panels) Lineage gates. Plots from one representative pair of animals are shown. (B) Total number of cells in the respective HSC subpopulation, as average per animal (2 tibiae, 2 femora). LT-HSC, CD34⁻Flt3⁻ LSK subset; ST-HSC, CD34⁺Flt3⁻ LSK subset; LMPP, CD34⁺Flt3⁺ LSK subset.