MiR-29c down-regulation is associated with higher level of Tcl1 oncogene. (A) Tcl1 protein levels in 10 CLL patients (5 miR-29c⁻ and 5 miR-29c⁺) detected by Western blot analysis reveal an association between miR-29c down-regulation and a higher Tcl1 expression. (B) Two-dimensional densitometry was used to quantify Tcl1 and actin protein band expression. This figure states Tcl1/actin ratios in miR-29c⁻ (n = 10) and miR-29c⁺ patients (n = 10). Statistical differences were assessed using the Mann-Whitney nonparametric test. The mean ratio in the 2 groups was plotted with their SEM.